PDF (28.38 mb) 2022 Corporate Fact Sheet. The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. CAS 9004-34-6, pH 5 - 7.5. ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? endstream Document(s): certificate data msds. CAS #: 9004-34-6 . The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. Performing this action will revert the following features to their default settings: Hooray! The most. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. Browse Avicel PH-101 and related products at MilliporeSigma. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. BIOACCUMULATIVE POTENTIAL zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. % The data shown below apply only to Avicel PH 101. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. Magazine: Material safety data sheet - FMC Corporation. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. The figure below illustrates the structural organisation of cellulose within plants. Revision No. ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" 1. Microcrystalline Cellulose. >> Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. Avicel PH-200 microcrystalline cellulose NF, Ph. w !1AQaq"2B #3Rbr Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. Home. 4. 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) Avicel Microcrystalline Cellulose Physical Properties. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. If breathing is difficult or if . CAS #: 9004-34-6 1.6. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, 1 0 obj cas:9000-11-7 msds Carboxymethyl cellulose. (&E. The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. SDS. MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. All rights reserved. Microcrystalline cellulose -The oldest polymer finds new industrial uses,. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . /MediaBox [0 0 612 792] %PDF-1.4 Explore how you can develop your career and bring your creative ideas to life at IFF. : 160182 Date Approved: 05/25/2010 Revision No. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. pH 6.0 to 8.0 . All Rights Reserved. Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. % Avicel Microcrystalline Cellulose: Chemical Identifiers. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. Avicel PC 611 (FMC Biopolymer) . AVICEL RC 581. Van Veen, G.K. Bolhuis, Y.S. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O MATERIAL SAFETY DATA SHEET Version: 1.0 1. . In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. <> This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. 1.3. However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? 51395-75-6 Avicel RC 591. <> Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. Cellulose microcrystalline. Validity Area. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. It is . <> ( <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 6 0 R/Group<>/Tabs/S>> pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. >> SDS - Safety Data Sheet. JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM Microcrystalline Cellulose; Cellulose; Functions. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. If you are already a ChemPoint customer then sign up for access to our online ordering website. 1.3. gwf;J(e0o|1p{R~P^);ao!%{0KD7. SUBSTANCE IDENTIFICATION 1.1. Eur., JPE . Apply today! Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. : 160182. Learn about FMC's industry leading goal of net-zero emissions by 2035. Explore how we work and why we apply science and creativity for a better world to everything we do. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. << CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. MCC helps in the formation of spheres because of its . We know that our customers need to provide reliable and consistent products to their patients. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. Biologicals by FMC. Go to Investor Relations. ( B;vLZpHU%ChUyD+[ Cellulose microcrystalline for column chromatography. <> F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. An agricultural sciences company. Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. A., and Smith, P. A. Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. Superior Performance: Provides excellent water uptake and rapid swelling . PDF (2.77 mb) 2021 FMC Sustainability Report. Product and Company Identification . Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. };khd5x=fr Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. Are you looking for information about products and services by region? Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . % The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. Some substance identifiers may have been claimed confidential, or may . IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. Microcrystalline Cellulose (MCC) MSDS 1. MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? The table below shows the most common physicochemical parameters of this raw material. q86@on$^X_HuH;3` Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. } !1AQa"q2#BR$3br lH5JWy}DgKRR"Fs They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. *r_ *?~4$ &0Y# 102331. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; stream Instead, they obtained a stable colloidal suspension. cas:9032-51-3 msds CELLULOSE PAB. /Contents 4 0 R Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. These grades have particle sizes ranging from <30 to approximately 200. Delivering efficient and robust formulations. endobj TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. POLYOX resins are nonionic polyethylene oxide solubility polymers. endobj 1 0 obj endobj You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. JFIF ` ` ZExif MM * J Q Q Q C Have an order or account question? (AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4( ESE;m& %QL((((((((((((((((((((((((((((((((((((((((P3NhC Trademarks: Avicel PH-102. EMCOCEL XLM 90. It is available in different grades and particle sizes. %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz Synergies to simplify formulation challenges and reduce operational costs. SUBSTANCE IDENTIFICATION 1.1. No. stream Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER Microcrystalline Cellulose / Avicel PH-102. Thus, Avicel contributes no or very few calories to the food system. EMCOCEL 90 M. 130. PharmaCentral 2021 . endobj endobj 4 0 obj Safety Data Sheet (SDS) Viewer. Manufacturer: FMC BioPolymer. Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe 4 0 obj %PDF-1.3 iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? However, it yields non-digestible fibre. ( FMC Corporation. MATERIAL SAFETY DATA SHEET. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. EINECS #: 232-674-9 1.7. >> In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. The typical mean particle size is 20200 m. Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets.
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